Flea Free Ectoline duo dog 20-40kg pipette 2 pieces

Flea Free Ectoline duo dog 20-40kg pipette
RVG NL 116241 AV

Ectoline duo 268mg/80mg spot-on solution for large dogs
Fipronil is an insecticide and acaricide belonging to the phenylpyrazoles. Fipronil and its metabolite fipronil sulfone act on the "ligand-regulated" chloride channels, in particular the channels regulated by the neurotransmitter Gamma-AminoButyric Acid (GABA) as well as the "desensitising" (D) and "non-desensitising" (N) channels regulated by glutamate (Glu, their unique regulated chloride channels, occurring exclusively in invertebrates), which bind to the chloride channel and thereby block the pre- and post-synaptic transfer of chloride ions across the cell membrane. This results in uncontrolled activity of the central nervous system, causing the insects and acarides to die.

Pyriproxyfen is an Insect Growth Regulator whose action is based on a juvenile hormone analogue effect. Pyriproxyfen sterilises adult fleas and prevents the development of immature stages. The molecule prevents, through contact, an increase in the number of adult fleas by inhibiting the development of their eggs (ovicidal action), larvae and pupae (larvicidal action), which then disappear.
If adult fleas ingest pyriproxyfen and/or come into contact with it, the molecule also sterilises the flea eggs during their development and before they are laid. The molecule prevents the contamination of the environment of treated animals with immature flea stages.

What is this product used for
For use in flea infestations alone or in combination with tick infestations.

Against fleas:
Treatment and prevention of flea infestations (Ctenocephalides felis). One treatment prevents further infestations for 7 weeks.
Prevention of the multiplication of fleas by preventing the development of adult fleas from flea eggs for 12 weeks after administration.

Against ticks:
Treatment of tick infestations (Ixodes ricinus).
One treatment provides persistent acaricidal efficacy against Ixodes ricinus for 2 weeks and against Dermacentor reticulatus and Rhipicephalus sanguineus for 4 weeks.
If some tick species (Dermacentor reticulatus, Rhipicephalus sanguineus) are already present at the time of administration of the veterinary medicinal product, it may be that not all ticks are killed within the first 48 hours

Do not use in
Do not use in rabbits, as side effects and even death may occur.

Do not use in cases of known hypersensitivity to the active substances or any of the excipients.

Active substances
Active substances 2.68 ml pipette:
Fipronil 268.0 mg
Pyriproxyfen 80.4 mg
Excipients
Butylhydroxyanisole 0.536 mg
Butylhydroxytoluene 0.268 mg

Excipients
Butylhydroxyanisole E320
Butylhydroxytoluene E321
Diethylene glycol monoethyl ether

Dosage
Apply one 2.68 ml pipette per dog weighing 20 to 40 kg, corresponding
to the minimum recommended dose of 6.7 mg fipronil/kg body weight and 2 mg
pyriproxyfen/kg body weight.

Volume - Dog weight - Fipronil (mg) - Pyriproxyfen (mg)
0.67 ml - 2-10 kg - 67 - 20.1
1.34 ml - 10-20 kg - 134 - 40.2
2.68 ml - 20-40 kg - 268 - 80.4
4.02 ml - 40-60 kg - 402 - 120.6
For dogs > 60 kg, the appropriate combination of pipettes should be used.

Directions for use
Remove the pipette from the blister pack. Hold the pipette upright. Tap the narrow end of the pipette to ensure that all the contents are in the reservoir of the pipette.
Break off the tip of the spot-on pipette along the break line. Push the dog's hair aside before the shoulder blades until the skin becomes visible. Place the tip of the pipette directly against the skin and gently squeeze the pipette several times to empty it. If necessary, the contents of the pipette can be applied at 1 or 2 additional locations to prevent the veterinary medicinal product from falling off the skin or being applied too superficially in the coat, especially in large dogs.

The treatment consists of one pipette, with the possibility of repeating the application monthly.
For optimal control of flea and tick infestations and the multiplication of fleas, the treatment schedule can be adapted to the epidemiological situation.

Read the package leaflet before use.
Read the package leaflet before use.
Observe the maximum daily dose.

Responsible for placing on the market
ALFAMED, 13ème rue – L.I.D., 06517 Carros Cedex, France