{"product_id":"flea-free-ectoline-duo-hond-20-40kg-pipet-2-stuks","title":"Flea Free Ectoline duo dog 20-40kg pipette 2 pieces","description":"\u003cb\u003eFlea Free Ectoline duo dog 20-40kg pipette\u003c\/b\u003e\u003cbr\u003e\u003cb\u003eRVG NL 116241 AV\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eEctoline duo 268mg\/80mg spot-on solution for large dogs\u003cbr\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazoles. Fipronil and its metabolite fipronil sulfone act on the \"ligand-regulated\" chloride channels, in particular the channels regulated by the neurotransmitter Gamma-AminoButyric Acid (GABA) as well as the \"desensitising\" (D) and \"non-desensitising\" (N) channels regulated by glutamate (Glu, their unique regulated chloride channels, occurring exclusively in invertebrates), which bind to the chloride channel and thereby block the pre- and post-synaptic transfer of chloride ions across the cell membrane. This results in uncontrolled activity of the central nervous system, causing the insects and acarides to die.\n\u003cbr\u003e\n\u003cbr\u003ePyriproxyfen is an Insect Growth Regulator whose action is based on a juvenile hormone analogue effect. Pyriproxyfen sterilises adult fleas and prevents the development of immature stages. The molecule prevents, through contact, an increase in the number of adult fleas by inhibiting the development of their eggs (ovicidal action), larvae and pupae (larvicidal action), which then disappear. \n\u003cbr\u003eIf adult fleas ingest pyriproxyfen and\/or come into contact with it, the molecule also sterilises the flea eggs during their development and before they are laid. The molecule prevents the contamination of the environment of treated animals with immature flea stages.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eWhat is this product used for\u003c\/b\u003e\u003cbr\u003eFor use in flea infestations alone or in combination with tick infestations.\n\u003cbr\u003e\n\u003cbr\u003eAgainst fleas:\n\u003cbr\u003eTreatment and prevention of flea infestations (Ctenocephalides felis). One treatment prevents further infestations for 7 weeks.\n\u003cbr\u003ePrevention of the multiplication of fleas by preventing the development of adult fleas from flea eggs for 12 weeks after administration.\n\u003cbr\u003e\n\u003cbr\u003eAgainst ticks:\n\u003cbr\u003eTreatment of tick infestations (Ixodes ricinus).\n\u003cbr\u003eOne treatment provides persistent acaricidal efficacy against Ixodes ricinus for 2 weeks and against Dermacentor reticulatus and Rhipicephalus sanguineus for 4 weeks.\n\u003cbr\u003eIf some tick species (Dermacentor reticulatus, Rhipicephalus sanguineus) are already present at the time of administration of the veterinary medicinal product, it may be that not all ticks are killed within the first 48 hours\u003cbr\u003e\u003cbr\u003e\u003cb\u003eDo not use in\u003c\/b\u003e\u003cbr\u003eDo not use in rabbits, as side effects and even death may occur.\n\u003cbr\u003e\n\u003cbr\u003eDo not use in cases of known hypersensitivity to the active substances or any of the excipients.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eActive substances\u003c\/b\u003e\u003cbr\u003eActive substances 2.68 ml pipette:\n\u003cbr\u003eFipronil 268.0 mg\n\u003cbr\u003ePyriproxyfen 80.4 mg\n\u003cbr\u003eExcipients\n\u003cbr\u003eButylhydroxyanisole 0.536 mg\n\u003cbr\u003eButylhydroxytoluene 0.268 mg\u003cbr\u003e\u003cbr\u003e\u003cb\u003eExcipients\u003c\/b\u003e\u003cbr\u003eButylhydroxyanisole E320\n\u003cbr\u003eButylhydroxytoluene E321\n\u003cbr\u003eDiethylene glycol monoethyl ether\u003cbr\u003e\u003cbr\u003e\u003cb\u003eDosage\u003c\/b\u003e\u003cbr\u003eApply one 2.68 ml pipette per dog weighing 20 to 40 kg, corresponding\n\u003cbr\u003eto the minimum recommended dose of 6.7 mg fipronil\/kg body weight and 2 mg\n\u003cbr\u003epyriproxyfen\/kg body weight.\n\u003cbr\u003e\n\u003cbr\u003eVolume - Dog weight - Fipronil (mg) -  Pyriproxyfen (mg)\n\u003cbr\u003e0.67 ml - 2-10 kg  -  67 - 20.1\n\u003cbr\u003e1.34 ml - 10-20 kg - 134 - 40.2\n\u003cbr\u003e2.68 ml - 20-40 kg - 268 - 80.4\n\u003cbr\u003e4.02 ml - 40-60 kg - 402 - 120.6\n\u003cbr\u003eFor dogs \u0026gt; 60 kg, the appropriate combination of pipettes should be used.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eDirections for use\u003c\/b\u003e\u003cbr\u003eRemove the pipette from the blister pack. Hold the pipette upright. Tap the narrow end of the pipette to ensure that all the contents are in the reservoir of the pipette.\n\u003cbr\u003eBreak off the tip of the spot-on pipette along the break line. Push the dog's hair aside before the shoulder blades until the skin becomes visible. Place the tip of the pipette directly against the skin and gently squeeze the pipette several times to empty it. If necessary, the contents of the pipette can be applied at 1 or 2 additional locations to prevent the veterinary medicinal product from falling off the skin or being applied too superficially in the coat, especially in large dogs.\n\u003cbr\u003e\n\u003cbr\u003eThe treatment consists of one pipette, with the possibility of repeating the application monthly.\n\u003cbr\u003eFor optimal control of flea and tick infestations and the multiplication of fleas, the treatment schedule can be adapted to the epidemiological situation.\n\u003cbr\u003e\n\u003cbr\u003eRead the package leaflet before use.\u003cbr\u003eRead the package leaflet before use.\u003cbr\u003eObserve the maximum daily dose.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eResponsible for placing on the market\u003c\/b\u003e\u003cbr\u003eALFAMED, \n13ème rue – L.I.D., \n06517 Carros Cedex, \nFrance","brand":"Flea Free","offers":[{"title":"2 Pieces","offer_id":50933200879946,"sku":"955909","price":24.38,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0924\/5497\/7866\/files\/8713112004041_A1N1.png?v=1753437353","url":"https:\/\/ithomepharma.com\/en\/products\/flea-free-ectoline-duo-hond-20-40kg-pipet-2-stuks","provider":"AtHomePharma","version":"1.0","type":"link"}